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Faculty Directory » Ronald Krieser

Biology/Chemistry

Office Hours:

Semester: Spring 2020
Monday 11:00am - 12:30pm
Tuesday 9:30am - 11:00am

Office Information:

Room Number: Antonucci Science Complex 338
Phone: 978.665.3619
Email: rkrieser@fitchburgstate.edu

Courses Taught:

General Biology I (BIOL 1800)
Genetics Lecture and Laboratory (BIOL 2800)
Biochemistry (BIOL 3450)
Molecular Biology (BIOL 4500)
Life Science II
Genetics of Disease

Education:

Postdoctoral work, Massachusetts General Hospital/Harvard Medical School, Dartmouth Medical School
Ph.D., Dartmouth College (Pharmacology and Toxicology)
B.A., Clark University (Biochemistry and Molecular Biology)

Research Interests:

I am interested in understanding the genetic control of apoptosis, a form of cell death during development and disease. I use the model organism Drosophila to study apoptosis and the disposal of the cell corpse in whole organism and tissue culture systems.

Representative Publications:

Abdelwahid, E. et al. (2007). "Mitochondrial disruption in Drosophila apoptosis." Developmental Cell, 12(5), pp. 793-806. doi: 10.1016/j.devcel.2007.04.004

Abdelwahid, E. et al. (2011). "Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death." Cell Death and Differentiation, 18, pp. 1640-1650. doi: 10.1038/cdd.2011.26

Barry, M.A. et al. (2003). "Lysosomal DNase II as a barrier to transfection." Molecular Therapy, 8(6), pp. 957-963. doi: 10.1016/j.ymthe.2003.09.011

Brachmann, C. et al. (2007). "The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis during development." Development, 134, pp. 2407-2414. doi: 10.1242/dev.02860

Eastman, A. & Krieser, R. (1998). "The cloning and expression of human deoxyribonuclease II: A possible role in apoptosis." Journal of Biological Chemistry, 273, pp. 30909-30914. doi: 10.1074/jbc.273.47.30909

Eastman, A. & Krieser, R. (1999)."Cleavage and nuclear translocation of the caspase 3 substrate Rho-GDP dissociation inhibitor D4-GDI during apoptosis." Cell Death and Differentiation, 6, pp. 412-419. doi: 10.1038/sj.cdd.4400515

Eastman, A. & Krieser, R. (2000). "Deoxyribonuclease II: structure and chromosomal localization of the murine gene, and comparison to the genomic structure of the human and three C. elegans homologs." Gene, 252(1-2), pp. 155-162. doi: 10.1016/S0378-1119(00)00209-2

Eastman, A. et al. (2001). "The cloning of genomic structure, localization, and expression of human deoxyribonuclease IIB." Gene, 269(1-2), pp. 205-216. doi: 10.1016/S0378-1119(01)00434-6

Eastman, A. et al. (2002). "Deoxyribonuclease II alpha." Biochemical and Biophysical Research Communication292, pp. 415-421.

Eastman, A. et al. (2003). "A family history of Deoxyribonuclease II: surprises from Trichinella spiralis and Burkholderia pseudomallei." Gene, 305(1), pp. 1-12. doi: 10.1016/S0378-1119(02)01233-7

Eastman, A. et al. (2003). "Structural requirements of human Deoxyribonuclease II a for formation of the active enzyme: the role of the signal peptide, N-glycosylation, and disulfide bridging." Biochemical Journal, 371(3), pp. 867-76. doi: 10.1042/bj20021875

Krieser, R. & White, K. (2002). "Engulfment Mechanisms of apoptotic cells." Current Opinion in Cell Biology, 14(6), pp. 734-738. doi: 10.1016/S0955-0674(02)00390-3

Krieser, R. & White, K. (2009). "Inside an enigma: do mitochondria contribute to cell death in Drosophila?" Apoptosis Journal, 14(8), pp. 961-968. doi: 10.1007/s10495-009-0362-6