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Faculty Directory » Mathangi Krishnamurthy


Office Hours:

Semester: Fall 2018
Wednesdays, 10:00-12:00
Thursdays, 1:00-3:00

Office Information:

Room Number: Antonucci Science Complex 227
Phone: 978-665-3976

Courses Taught:

Organic Chemistry I (CHEM 2000)
Organic Chemistry II (CHEM 2100)
Medicinal Chemistry (CHEM 4020)
Chemistry for Health Sciences (CHEM 1200)


Postdoctoral fellow, Howard Hughes Medical Institute/Harvard Medical School/Massachusetts General Hospital
Ph.D. Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis
B. Pharm, The TamilNadu Dr. MGR Medical University, Chennai, India

Research Interests:

Rational drug design and synthesis
Development of new DNA minor groove binders and intercalators with anticancer activity

Representative Publications:

Nadipuram AK, Krishnamurthy M, Ferreira AM, Li W, and Moore BM II, “Synthesis and Testing of Novel Classical Cannabinoids: Exploring the Side Chain Ligand Binding Pocket of the CB1 and CB2 Receptors,” Bioorganic & Medicinal Chemistry, 11, 3121-3132 (2003).

Krishnamurthy M, Ferreira AM, and Moore BM II, “Synthesis and Testing of Novel Phenyl Substituted Side-Chain Analogues of Classical Cannabinoids,” Bioorganic & Medicinal Chemistry Letters, 13, 3487-3490 (2003).

Krishnamurthy M, Li W, and Moore BM II, “Synthesis, biological evaluation, and structural studies on N1 and C5 substituted cycloalkyl analogues of the pyrazole class of CB1 and CB2 ligands,” Bioorganic & Medicinal Chemistry, 12, 393-404 (2004).

Ferreira AM, Moore BM II, and Krishnamurthy M, “Theoretical analysis of the NMR and electronic structure of novel Δ8-THC derivatives,” Journal of Molecular Structure: THEOCHEM, 674, 131-138 (2004).

Duntsch C, Divi MK, Jones T, Zhou Q, Krishnamurthy M, Boehm P, Wood G, Sills A, and Moore BM II,  "Safety and efficacy of a novel cannabinoid chemotherapeutic, KM-233, for the treatment of high-grade glioma,” Journal of Neuro-Oncology, 77, 2,143-152 (2006).

Krishnamurthy M, Gurley S, and Moore BM II, “Exploring the substituent effects on a novel series of C1'-dimethyl-aryl ?8-tetrahydrocannabinol analogs, “ Bioorganic & Medicinal Chemistry, 16, 6489-6500 (2008).

Mansy SS, Schrum JP, Krishnamurthy M, Tobé S, Treco DA, and Szostak JW, "Template-directed synthesis of a genetic polymer in a model protocell," Nature, 454, 122-125 (2008).

Ferreira AM, Krishnamurthy M, Moore BM II, Finkelstein D, and Bashford D, “Quantitative structure-activity relationship (QSAR) for a series of novel cannabinoid derivatives using descriptors derived from semi-empirical quantum-chemical calculations,” Bioorganic & Medicinal Chemistry, 17, 2598-2606 (2009).

Schrum JP, Ricardo A, Krishnamurthy M, Blain C, and Szostak, JW, "Efficient and Rapid Template-Directed Nucleic Acid Copying using 2′-amino-2′, 3′-dideoxyribonucleoside-5′- phosphorimidazolide Monomers," Journal of the American Chemical Society, 131, 40, 14560-70 (2009).

Professional Affiliations:

Member, American Chemical Society
Member, Rho Chi Pharmacy Honor Society, Alpha Nu Chapter

Current Patents
Moore BM II, Ferreira AM, and Krishnamurthy M, “Cannabinoid Derivatives, Methods of Making and Use thereof”, U.S. Patent No. 7169942, Issue date: Jan 30, 2007.