Eric Williams, Ph.D., Biology and Chemistry | Fitchburg State University
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Faculty Directory » Eric O. Williams

Biology/Chemistry

Office Hours:

Semester: Fall 2020
Via Google Meet: https://meet.google.com/jnm-mbqx-asv
Tuesday 3:00 4:00pm
Wednesday 11:30am - 1:30pm

Office Information:

Room Number: Antonucci Science Complex 235
Phone: 978.665.3763
Email: ewilli28@fitchburgstate.edu

Courses Taught:

Anatomy and Physiology I (Lecture and Laboratory) (BIOL 1200)
General Biology (Laboratory) (BIOL 1800)
Developmental Biology (BIOL 3550)
Cancer Genomics (BIOL 4009)

Education:

Ph.D., Cornell University (Neurobiology & Behavior)
B.A., Cornell University (Genetics & Developmental Biology)

Research Interests:

I study a rare form of human muscular dystrophy called dysferlinopathy. This disease is caused by mutations in the dysferlin gene and results in the loss of membrane repair in human skeletal muscle. We use the C. elegans worm to model the disease. These worms have a conserved homologous gene, which is also called dysferlin. Mutations in C. elegans dysferlin results in membrane fusion defects in developing sperm, ultimately causing sterility. The aim of my research is to rescue the sterility of these worms and then apply that knowledge to the human disease, with the ultimate goal of identifying a way to treat this rare form of muscular dystrophy.

Representative Publications:

Arany, Z. et al. (2018). "Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging." Cell173(1), pp. 74-89. doi: 10.1016/j.cell.2018.02.008

Bell, E.L. et al. (2014). "Guarente L. SirT1 is required in the male germ cell for differentiation and fecundity." Development, 141(18), pp. 3495-504. doi: 10.1242/dev.110627

Bell, E.L. et al. (2013). "SIRT1 Suppresses the Epithelial-to- Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis." Cell Reports, 3(4), pp. 1175-86. 10.1016/j.celrep.2013.03.019

Bell, E.L. et al. (2016). "Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency." Cell Reports, 17(3), pp. 809-820. doi: 10.1016/j.celrep.2016.09.046

Bisogni, A.J. et al. (2018). Tuning of delta-protocadherin adhesion through combinatorial diversity. Elife7, e41050. doi: 10.7554/eLife.41050

Bogush, A. et al. (2008). "Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis." Experimental Neurology, 213(1), pp. 229-37. doi: 10.1016/j.expneurol.2008.06.010

Dooley, A.L. et al. (2011). "Delta Protocadherin 10 is regulated by activity in the mouse main olfactory system." Front Neural Circuits, 5(9). doi: 10.3389/fncir.2011.00009

Guarente, L. et al. (2019). "NAD+ supplementation rejuvenates aged gut adult stem cells." Aging Cell, 18(3), e12935. doi: 10.1111/acel.12935

Lin, D.M. et al. (2007). "Novel subdomains of the mouse olfactory bulb defined by molecular heterogeneity in the nascent external plexiform and glomerular layers." BMC Developmental Biology, 7(48). doi: 10.1186/1471-213X-7-48