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Faculty Directory » Eric O. Williams


Office Hours:

Semester: Fall 2019
Wednesday 9:30am - 11:00am
Friday 9:30am - 11:00am

Office Information:

Room Number: SCI 235
Phone: (978) 665-3763

Courses Taught:

Anatomy and Physiology I (Lecture and Laboratory) (BIOL 1200)
General Biology (Laboratory) (BIOL 1800)
Developmental Biology (BIOL 3550)
Cancer Genomics (BIOL 4009)


Ph.D., Cornell University (Neurobiology & Behavior)
B.A., Cornell University (Genetics & Developmental Biology)

Research Interests:

I study a rare form of human muscular dystrophy called dysferlinopathy. This disease is caused by mutations in the dysferlin gene and results in the loss of membrane repair in human skeletal muscle. We use the C. elegans worm to model the disease. These worms have a conserved homologous gene, which is also called dysferlin. Mutations in C. elegans dysferlin results in membrane fusion defects in developing sperm, ultimately causing sterility. The aim of my research is to rescue the sterility of these worms and then apply that knowledge to the human disease, with the ultimate goal of identifying a way to treat this rare form of muscular dystrophy.

Representative Publications:

Igarashi M, Miura M, Williams E, Jaksch F, Kadowaki T, Yamauchi T, Guarente L. NAD+ supplementation rejuvenates aged gut adult stem cells. Aging Cell. 2019 Jun;18(3):e12935

Bisogni AJ, Ghazanfar S, Williams EO, Marsh HM, Yang JY, Lin DM. Tuning of delta-protocadherin adhesion through combinatorial diversity. Elife. 2018 Dec 14;7:e41050

Das A, Huang GX, Bonkowski MS, Longchamp A, Li C, Schultz MB, Kim LJ, Osborne B, Joshi S, Lu Y, Treviño-Villarreal JH, Kang MJ, Hung TT, Lee B, Williams EO, Igarashi M, Mitchell JR, Wu LE, Turner N, Arany Z, Guarente L, Sinclair DA. "Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging," Cell 2018 Mar 22; 173(1):74-89. PMID: 29570999

Williams EO, Taylor AK, Bell EL, Lim R, Guarente LP. "Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency," Cell Reports 2016 Oct;17(3): 809-820. PMID: 2773285

Bell EL, Nagamori I, Williams EO, Rosario AD, Bryson BD, Watson N, White FM, Sassone-Corsi P. "Guarente L. SirT1 is required in the male germ cell for differentiation and fecundity," Development 2014 Sep;141(18):3495-504. PMID: 25142464

Simic P, Williams EO, Bell EL, Gong JJ, Bonkowski M, Guarente L. "SIRT1 Suppresses the Epithelial-to- Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis," Cell Reports 2013 Apr 25;3(4): 1175-86. PMID: 23583181

Williams EO, Sickles HM, Dooley AL, Palumbos S, Bisogni AJ, Lin DM. "Delta Protocadherin 10 is regulated by activity in the mouse main olfactory system," Front Neural Circuits 2011;5:9 Aug 23. PMID: 21897809

Boston-Howes W*, Williams EO*, Bogush A, Scolere M, Pasinelli P, Trotti D. "Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis," Experimental Neurology 2008 Sep; 213(1):229-37 PMID: 18625223 *co-authorship

Williams EO, Xia Y, Sickles HM, Shafer P, Yona G, Yang JY, Lin DM. "Novel subdomains of the mouse olfactory bulb defined by molecular heterogeneity in the nascent external plexiform and glomerular layers," BMC Developmental Biology 2007 May 16;7:48. PMID: 17506891